Literature summary for 2.7.10.2 extracted from

Liu, H.; Cui, Y.; Wang, G.; Dong, Q.; Yao, Y.; Li, P.; Cao, C.; Liu, X.
The nonreceptor tyrosine kinase c-Abl phosphorylates Runx1 and regulates Runx1-mediated megakaryocyte maturation (2018), Biochim. Biophys. Acta Mol. Cell Res., 1865, 1060-1072 .

Search for more literature for 2.7.10.2

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
nilotinib	AMN107	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + [Runx1]-L-tyrosine	Homo sapiens	the enzyme phosphorylates transcription factor Runx1 and regulates Runx1-mediated megakaryocyte maturation	ADP + [Runx1]-L-tyrosine phosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9QVP9	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
bone marrow	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + [Runx1]-L-tyrosine	-	Homo sapiens	ADP + [Runx1]-L-tyrosine phosphate	-	?
ATP + [Runx1]-L-tyrosine	the enzyme phosphorylates transcription factor Runx1 and regulates Runx1-mediated megakaryocyte maturation	Homo sapiens	ADP + [Runx1]-L-tyrosine phosphate	-	?

Synonyms

Synonyms	Comment	Organism
c-Abl tyrosine kinase	-	Homo sapiens
nonreceptor tyrosine kinase c-Abl	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	increased numbers of megakaryocytes are detected in the spleens and bone marrow of Abl gene conditional knockout mice	Homo sapiens
physiological function	c-Abl kinase plays an important role in Runx1-mediated megakaryocyte maturation and platelet formation. The enzyme mediates phosphorylation of Y376 and Y387 in the Runx1 transcription inhibition domain that negatively regulates the transcriptional activity of Runx1, leading to inhibition of Runx1-mediated megakaryocyte maturation	Homo sapiens

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Release 2023.1 (January 2023)